Alagille syndrome is a rare multisystem disorder that primarily affects the liver, heart, and kidneys, and is most frequently associated with pathogenic mutations in the JAG1 gene, with a smaller ...

A team of researchers at Baylor College of Medicine, UMass Chan Medical School and Cincinnati Children's Hospital Medical Center has developed a new treatment that could change the outlook for ...

Alagille syndrome, a genetic disease estimated to affect 1 in 30,000 individuals, is caused by mutations in the gene JAG1 in most cases. The mutations affect multiple organs including the liver where ...

An Ipsen drug developed to treat the severe itching that accompanies certain liver disorders is now FDA approved for treating this complication in patients with Alagille syndrome. It’s the second ...

ATTICA, N.Y. (WKBW) — J'Mari Hicks is a typical two-year-old who loves to run, play and watch Mickey Mouse — but unlike his peers, J'Mari needs a living liver donation. Last year, J'Mari was diagnosed ...

Credit: Getty Images. The sNDA is supported by data from the ASSERT study, which included patients less than 17 years old with genetically confirmed Alagille syndrome. The Food and Drug Administration ...

A drug to treat severe itching in patients with Alagille syndrome should be granted a marketing authorization in the European Union under what the European Medicines Agency (EMA) termed exceptional ...

Event-Free Survival Data from Mirum’s LIVMARLI Alagille Syndrome Program Published in Hepatology Improvement in pruritus, serum bile acid levels and bilirubin were highly predictive of six-year ...