Thus, the present study has shown that d-Asb11 is a positive regulator of Notch signalling, probably acting at the level of DeltaA ubiquitylation and thereby regulating Notch signalling activity in a ...

While the role of barrier function in establishing a protective, nutrient-rich, and ionically balanced environment for neurons has been appreciated for some time, little is known about how signaling ...

A report in the January 24 online Journal of Biological Chemistry indicates that the Notch ligands Delta and Jagged are also substrates for γ-secretase, the intramembrane aspartyl protease responsible ...

Researchers have made a surprising discovery linking Delta/Notch signaling in subperineurial glia (SPG) to the regulation of nerve ensheathment and neurotransmitter release at the Drosophila ...