Fred Hutch

Exit or not? HSV-1 infection redistributes heterochromatin to exit the nucleus

A recent study In Press at the Journal of Cell Biology reports that herpes simplex virus 1 (HSV-1) exploits heterochromatin to successfully exit the nucleus. The heterochromatin markers macroH2A1 and ...
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The structure of HSV-1 gB bound to a potent neutralizing antibody reveals a conservative antigenic domain across herpesviruses

(A) Cryo-EM structure overview of HSV-1 gB in complex with D48 Fab. The side view and top view were presented. The HSV-1 gB trimer and D48 Fab VH/VL were colored differently. (B) Neutralization assay ...
Health on MSN

Herpes Simplex Virus 1 vs. Herpes Simplex Virus 2—Understanding the Difference

HSV-1 usually causes oral herpes, while HSV-2 primarily affects the genitals. You may not know you have herpes because it ...
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The structure of HSV-1 gB in complex with D48 Fab and structural and sequence comparison with HCMV and EBV gB with their neutralization antibody reveal DII as a conservative ...

(A) Cryo-EM structure overview of HSV-1 gB in complex with D48 Fab. The side view and top view were presented. The HSV-1 gB trimer and D48 Fab VH/VL were colored differently. (B) Neutralization assay ...