The Chan Zuckerberg Initiative (CZI) announced four multi-year Exploratory Cell Networks grants for researchers exploring the frontiers of genomics, cell biology, and synthetic biology by developing ...

Protein kinases are key regulators of various biological processes, such as control of cell growth, metabolism, differentiation and apoptosis. Therefore, protein kinases have been an important class ...

Arguably the most prominent target for drug development these days is kinase-directed therapy. Almost daily, there are news reports, articles, patents, and clinical trials describing how kinase ...

When it comes to finding therapeutic cancer targets, “mutated cancer genes are just the tip of the iceberg, but functional genomics can help uncover the much larger, submerged portion of the iceberg,” ...

To solve the kinome of Dictyostelium, Dr. Smith and her colleagues at Boston Biomedical utilized the power of bioinformatics, a cutting edge scientific technique which employs databases and computer ...

Kinases have emerged in recent years as promising targets for therapeutic intervention, unsurprisingly, as mutations in kinase domains have been linked to an array of human disorders—most notably ...

Aptose Biosciences Inc. has bought over the worldwide rights to Hanmi Pharmaceutical Co. Ltd.’s myeloid kinome inhibitor in a deal worth up to $420 million. Seoul, South Korea-based Hanmi has granted ...

Safety interim analysis (SIA) of atractib: A phase 2 trial of first-line (1L) atezolizumab (A) in combination with paclitaxel (P) and bevacizumab (B) in metastatic triple-negative breast cancer (mTNBC ...

Investigation of non-V600 BRAF mutations commonly found in NSCLC for their sensitivity to dabrafenib or trametinib. Genomics, transcriptomics, and proteomics in the clinical setting: Integrating whole ...

If a genome refers to the genetic sequences of an organism, and proteome refers to the proteins of an organism, what, you might wonder, is a kinome? Funny you should ask. A kinome refers to the ...