Mitochondrial protein import is a critical process underpinning mitochondrial biogenesis and cellular homeostasis. With the vast majority of mitochondrial proteins encoded by nuclear DNA and ...

A defect in mitochondrial tRNA modification impairs the proper formation of mitochondrial OXPHOS complexes, which results in iron transmigration from mitochondria to cytosol. Excess cytosolic iron ...

A research collaboration has found that besides regulating the fusion of mitochondria, Mitofusin 2 also ensures protein quality control. This discovery could open up new routes to treating ...

One key enzyme in this process is MTO1, which facilitates mitochondrial protein synthesis by modifying mitochondrial tRNAs. It is known as an important enzyme indispensable for survival, and mutations ...

In a new study, researchers from Japan demonstrate that COX7RP, a mitochondrial protein, may play a key role in enhancing mitochondrial energy efficiency, leading not only to longer lifespans but also ...

Calcium transport into and out of mitochondria -- the powerhouses of cells -- is central to cellular energy production and cell death. To maintain the balance of calcium within these powerhouses, ...

Longevity science has spent decades chasing single molecules that might slow aging, but most candidates have delivered modest, inconsistent results. A new line of research is now pointing to a ...

The study results, published June 5 in The EMBO Journal, shed new light, researchers say, on the way the altered mitochondrial membranes found in people with metabolic diseases such as Barth syndrome, ...

By Tarun Sai Lomte New evidence from Indian patients shows that severe COVID-19 is associated with distinct mitochondrial ...