Immune checkpoint blockade (ICB) therapy has transformed cancer treatment, but many tumors remain resistant. A new study from ...

Immune checkpoint blockade (ICB) therapy has transformed cancer treatment, but many tumors remain resistant. A new study from ...

The p53 tumor suppressor protein is encoded by TP53, the most frequently mutated gene in cancer. A review article published in Nature Reviews Clinical Oncology by Professor Klas G Wiman and colleagues ...

Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers—about a millionth of a milliliter. The cell manages this by ...

Can networks of genes be stimulated using resonance? Researchers at the Niels Bohr Institute are investigating whether the protein p53, which activates a range of different genes, can be induced to ...

The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA ...

The development of cancer after p53 inactivation is determined by a series of genomic changes that occur in four steps. The loss of heterozygosity of TP53 (the gene encoding p53 in humans, named Trp53 ...

Researchers have discovered that aneuploidy drives gain-of-function phenotypes in cells expressing mutant p53. Their report has implications for developing therapies targeting mutant p53. The tumor ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney Kimmel ...

Phase II study to evaluate surufatinib in patients with osteosarcoma and soft tissue sarcoma that has failed standard chemotherapy: Updated analysis. This is an ASCO Meeting Abstract from the 2024 ...