Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...
A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryo-EM microscope’s contrast, allowing biologists to ...
Researchers at University of Tsukuba have achieved high-resolution visualization of cellular organelles, such as nuclei and mitochondria, using an external apodized phase contrast (ExAPC) microscope.
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