The phosphoinositide-3-kinase-like protein kinases ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and Rad3-related (ATR) signal in response to chromosomal DNA damage by ...
The DNA contained in every mammalian cell is under constant attack by agents that can either directly damage one of its three billion bases or break the phosphodiester backbone on which the bases ...
These two images demonstrate synthetic lethality with a non-responsive cell line (right) compared to a responder to ATR +PKMYT1 inhibition (left). As demonstrated by the long strands, the ...
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