A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...
One key enzyme in this process is MTO1, which facilitates mitochondrial protein synthesis by modifying mitochondrial tRNAs. It is known as an important enzyme indispensable for survival, and mutations ...
A defect in mitochondrial tRNA modification impairs the proper formation of mitochondrial OXPHOS complexes, which results in iron transmigration from mitochondria to cytosol. Excess cytosolic iron ...
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