Ribosomes are tiny molecular machines inside all living cells that build proteins, and ribosome biogenesis is the complex, multi-step process by which they are made. During brain development, neural ...

A team led by UT Southwestern Medical Center scientists has identified a specific stage of neurodevelopment when differentiating neural cells produce fewer ribosomes, which are responsible for making ...

Schematic of ribosome biogenesis. Eukaryotic ribosome biogenesis involves RNA polymerases I/II/III (Pol I, Pol II, and Pol III), transcribing rDNA to rRNA, and producing 47S pre-rRNA in the nucleolus.

Ribosomes are the cell's protein factories, which read the genetic code and assemble the proteins that every organism needs to live. But as far as how ribosomes themselves were formed, tantalizingly ...

The discovery of ribosomes dates back to the 1950s, when George Palade first observed dense particles in the cytoplasm of cells using electron microscopy. These particles were later named "ribosomes" ...

MYC is a key regulator of RNA Polymerase I (Pol I) transcription, promoting rRNA synthesis both directly and indirectly. MYC overexpression is common in many cancer types, where it drives increased ...

This new review article highlights the critical role of ribosome biogenesis in liver health and disease progression. As the center of protein synthesis, ribosomes influence liver regeneration, ...

A single iron-sulfur building block directly determines whether ribosomes—the protein factories of our cells—work smoothly or not. This is the conclusion of a recent research project led by the RPTU ...