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Medical explainer on Instagram: "The immediate action of intravenously injected adenosine is extremely rapid and short-lived, primarily targeting the Atrioventricular (AV) node in the heart. ⚡ Immediate Action: AV Nodal Blockade/Slowing: Adenosine binds to A_1 receptors in the AV node, which leads to: Slowing of conduction time through the AV node. Interruption of re-entry pathways that rely on the AV node. This effect can momentarily cause a short-lasting heart block (first, second, or third de
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Anesthesia Buddy on Instagram: "Adenosine ⚡🫀⁣ ⁣ Mechanism of action⁣ Adenosine binds A1 receptors in the AV node → Gi protein activation → ↓ cAMP → ↓ Ca²⁺ influx⁣ Result: hyperpolarization of AV nodal cells and transient AV block⁣ Onset: seconds⁣ Half-life: ~10 seconds (rapid uptake by RBCs and vascular endothelium)⁣ ⁣ Airway & anesthesia implications ⚠️⁣ Can cause bronchospasm via A2B receptors⁣ Avoid or use extreme caution in asthma or reactive airway disease⁣ Expect flushing, chest tightness
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